Immunity training
What is immunity training?
Most immune supplements are built to boost after you're already run down. Immunity training is the daily alternative: build the foundation before you need it.
Built on the cutting-edge science of trained immunity. Every nutrient dosed exactly as the label says, and every batch tested before release.
Boosting vs training
Boosting reacts; training prepares.
A boost is a reaction: something you reach for once you're already run down. Immunity training is a routine you keep, a daily multivitamin built on the science of trained immunity, so the foundation is in place before you need it.
| The difference | Boostingthe old way | TrainingbyMae |
|---|---|---|
| When you reach for it | Once you're already run down. | As part of a daily routine, before you need it. |
| What it is | A megadose of one thing: zinc, elderberry, a vitamin C powder. | A complete daily multivitamin with clinically-studied yeast beta-glucan. |
| What it's built on | The reflex to react. | The science of trained immunity, credited to the researchers who found it. |
| Where it ends up | Back on the shelf until the next time. | A foundation that's already in place, all year. |
The science, credited
Trained immunity is the researchers’ discovery.
Trained immunity is a kind of memory scientists found in the innate immune system, your first line of defense. Dr. Mihai Netea’s group at Radboud University named it in 2011, and research since then has looked at how innate immune cells respond differently after an earlier encounter.
For more than a century the innate side of the immune system was thought to have no memory at all. Trained immunity overturned that, and it is now studied in labs around the world. Netea won the 2016 Spinoza Prize, the highest science award in the Netherlands, for the work.
byMae is built on the science of trained immunity. The research is the researchers’ own: multi+ hasn’t had a clinical trial of its own, and no study has measured trained immunity in people taking it.
The research, by title
Trained immunity: A program of innate immune memory in health and disease.
Netea MG, Joosten LAB, Latz E, et al. · Science · 2016
Read the paper →Spinoza Prize 2016 — Prof. Mihai Netea.
Netherlands Organisation for Scientific Research (NWO) · NWO · 2016
Read the paper →β-1,3/1,6-Glucans and Immunity: State of the Art and Future Directions.
De Marco Castro E, Calder PC, Roche HM. · Molecular Nutrition & Food Research · 2021
Read the paper →Recognition of yeast β-glucan particles triggers immunometabolic signaling required for trained immunity.
Study authors · PMC · 2024
Read the paper →Potent induction of trained immunity by Saccharomyces cerevisiae β-glucans.
Vuscan P, et al. · Frontiers in Immunology · 2024
Read the paper →
The ingredient
Clinically-studied yeast beta-glucan.
Beta-glucan is a natural fiber from baker’s yeast. Your innate immune cells recognize its shape, which is why scientists have been studying it for decades.
The lab studies above looked at yeast beta-glucan. It is in every multi+ format, beside the daily essentials; the amount for each format is on its product page and its Supplement Facts panel.
multi+, the product system.
Drink or capsules for adults, with 22 essential nutrients plus clinically-studied yeast beta-glucan. Mixed-berry chewables for littles, with 17 essential vitamins and minerals plus beta-glucan. The Flex Bundle has both adult formats. Dosage-accurate: what's on the label is what's in every serving. Every batch is tested before release.
How to take it
One serving a weekday.
20 servings to a pack, a month’s supply.
Adults: one serving of multi+ Drink or Capsules, Monday through Friday.
Littles: Ages 2 to 3: 1 chewable. Ages 4 and up: 2 chewables. Monday through Friday, with food.
A pack of 40 chewables lasts about a month at two a weekday (ages 4 and up) and about two months at one (ages 2 to 3).
Skip, move or cancel anytime.
Weekdays are when you’re out in the world the most. It’s also the schedule we tend to run on, and a routine that follows that rhythm is easier to keep. Five days a week is the full routine.
Questions about immunity training.
Immunity training is a daily routine that builds the foundation before you need it. Most immune supplements are built to boost after you’re already run down; immunity training is the daily alternative.
byMae builds it into a daily multivitamin, multi+: 22 essential nutrients for adults, 17 essential vitamins and minerals for littles, plus yeast beta-glucan.
No. Boosting reacts; training prepares. A boost is something you reach for once you’re already run down. Immunity training is a routine you keep, so the foundation is in place before you need it.
Trained immunity is a kind of memory scientists found in the innate immune system, your first line of defense. Dr. Mihai Netea’s group at Radboud University named it in 2011, and research since then has looked at how innate immune cells respond differently after an earlier encounter.
byMae is built on that science. The research is the researchers’ own: multi+ hasn’t had a clinical trial of its own, and no study has measured trained immunity in people taking it.
multi+ is byMae’s product system. Drink and Capsules for adults each carry 22 essential nutrients plus clinically-studied yeast beta-glucan. Littles is a mixed-berry chewable with 17 essential vitamins and minerals plus beta-glucan, and less than 1 g of sugar per chewable. The Flex Bundle is both adult formats.
Dosage-accurate: what's on the label is what's in every serving. Every batch is tested before release. Every ingredient and its amount is on the Ingredients page.
One serving a weekday. 20 servings to a pack, a month’s supply. Adults take one serving of Drink or Capsules, Monday through Friday.
Ages 2 to 3: 1 chewable. Ages 4 and up: 2 chewables. Monday through Friday, with food.
Adults 18 and up, with multi+ for adults, and kids 2 and up, with multi+ for littles.
multi+ for adults isn’t a prenatal, so we don’t recommend it while you’re pregnant or nursing. If you take medication or are being treated for a condition, check with your healthcare provider first. For a child, show your pediatrician the label.
30 days to try it. If it isn’t earning its place on your shelf or in your routine, we’ll refund it. Email support@bymae.com. Nothing to send back.
Go deeper
Keep learning about immunity training
Plain-language reads on immunity training: what it is, how it differs from a boost, and what the research on yeast beta-glucan has looked at.
Beta-Glucan Explained: The Science of Immunity Training & Resilience
What is beta-glucan, how does it work, and is it safe for daily use? Clear, research-backed answers about the natural fiber from baker’s yeast.
Read the articleA Parent’s Guide to a Toddler’s Immune System
How a toddler’s immune system works, and where a daily multivitamin fits.
Read the articleYour Immune System Just Got a Promotion: Resilience in Your 40s
In your 40s you become the shock absorber for everyone. Why your immune system’s job just got bigger — and a playbook for everyday resilience.
Read the article
- Every ingredient, explained
The full formula, nutrient by nutrient: what beta-glucan and each vitamin and mineral does, and the form and amount byMae uses.
- Compare byMae
Honest, side-by-side comparisons of byMae against other multivitamins and everyday immune supplements.
- Immunity training for your life
See how the same routine fits families, individuals, active adults, and travelers.
The fine print made clear
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.